Endocrine Abstracts

Aim: Organoid cultures are a powerful model system for the study of cell biology and human disease. Manipulation of the composition of the culture medium has been used to promote cellular differentiation in gastric organoids to allow more accurate modelling of the mature epithelial cells present in the stomach. However, methods to promote the differentiation of neuroendocrine cells and specifically enterochromaffin-like (ECL)-cells within a gastric organoid system have not yet...

Background: Appendiceal neuroendocrine tumours (aNETs) are usually diagnosed incidentally at appendicectomy, are indolent and rarely recur.Methods: We retrospectively analysed patients diagnosed with aNETs and entered prospectively into our tertiary referring centre’s NET database between 1990 and 2016.Results: 102 patients (F:M ratio of 1.04:1) presented with aNET at a median age of 39.4 (range 16.3–81.1) years. Average ...

Background: Current ENET guidelines inform our management of GCCs but we still have poor understanding of how these tumours behave in clinical practice.Methods: We retrospectively analysed patients diagnosed with GCCs and entered prospectively into our tertiary referring centre’s NET database between 1990 and 2016.Results: 41 patients (F:M ratio of 1.28:1) presented with GCC at a median age of 61 (range 27–79) years. Aver...

Introduction: Non-functioning pituitary macroadenoma (NFMA) can cause considerable morbidity due to pituitary dysfunction and pressure effects. We present recent experience in managing cases diagnosed with NFMA at a single tertiary centre between January 2009 and October 2013.Results: Of the 63 patients with NFMA, 28 (44%) were females. Age ranged from 22 to 91 (mean 63). Visual disturbance symptoms (35/63; 57%) were the commonest presentation. Headache ...

Introduction: LAN, a somatostatin analogue, is a common first-line treatment for NETs. LAN comes as a pre-filled, ready-to-use syringe, administered every 4 weeks. In the UK, patients may receive LAN at home. The aim of PREF-NET was to generate real-world evidence describing patient’s experience of LAN administered in homecare and hospital settings, and the associated impact of treatment setting on other areas of patients’ lives.Methods: PREF-N...

Background: Pancreatic neuroendocrine tumours (panNETs) may arise as part of an underlying genetic condition such as multiple endocrine neoplasia type 1 (MEN type 1). The value of functional imaging using 68Ga-labelled synthetic octreotide analogues using PET-CT has not been extensively evaluated in patients with MEN1 to determine its value.Methods: We investigated the effect of 68Ga-based PET-CT imaging on patient management in pat...